Though I travel some for work, I'm no 100,000K road warrior. These folks can spend hours discussing the pros and cons of luggage brands, styles and proper stacking strategies. They are likely to carry duct tape.
Not quite as seasoned--"stacking challenged," as my colleague Stephanie likes to say--I find it hard to balance the laptop atop the rollaboard. Me and my luggage? A bit like watching the Three Stooges navigate the escalators, moving sidewalks, TSA agents, trains and shuttles involved in modern air transport.
But the knitting thing. That I got down. For domestic trips I carry the following: A small circular needle case with a variety of needle sizes, wood and metal, a Chibi, needle gauge and The Knit Kit--a fabulous gizmo. The circular needle cases are large enough to accommodate small projects or even a sweater sleeve along with all the tools. (Mine was a promotion; but here's a similar one).
Happy trails, everyone!